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tocriscreen stem cell library  (Tocris)


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    Tocris tocriscreen stem cell library
    ( A ) Bar plot representing the distribution of targets for the 92 compounds included in the screen. ( B ) Schematic of the experimental design for the small molecule screen. ( C ) UMAP of the MG and MG-derived <t>cell</t> types. Cells are colored by cell type. ( D ) UMAP from C with cells colored by collection. ( E ) Dot plot of the genes used to define the MG-derived cell types from the screen. Dot size indicates the percent of cells that express the gene of interest. The color indicates the log10 mean UMIs per cell. ( F ) Quantification of the fold change in Neuron cell counts between each indicated condition and the Ascl1 only control. The plots from Collections 1 and 2 used only the control wells collected on their respective days. The dose of each compound is indicated by the size of the dot. ( G ) Quantification of the total cell counts for each treatment. The compound’s dose is indicated by the size of the dot. ( H ) Plots displaying the fold change of Neuron (red) and ProL (orange) cell counts compared to Ascl1 only across all doses for the top hits from the screen. All conditions in which at least 20 cells were recovered are displayed. Figure 2B is created with BioRender.com . Figure 2—source data 1. Small molecules used from <t>Tocriscreen</t> <t>Stem</t> Cell <t>Library.</t> Figure 2—source data 2. Genes used and GO annotations in unknown clusters.
    Tocriscreen Stem Cell Library, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 10 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tocriscreen stem cell library/product/Tocris
    Average 93 stars, based on 10 article reviews
    tocriscreen stem cell library - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia"

    Article Title: A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    Journal: eLife

    doi: 10.7554/eLife.92091

    ( A ) Bar plot representing the distribution of targets for the 92 compounds included in the screen. ( B ) Schematic of the experimental design for the small molecule screen. ( C ) UMAP of the MG and MG-derived cell types. Cells are colored by cell type. ( D ) UMAP from C with cells colored by collection. ( E ) Dot plot of the genes used to define the MG-derived cell types from the screen. Dot size indicates the percent of cells that express the gene of interest. The color indicates the log10 mean UMIs per cell. ( F ) Quantification of the fold change in Neuron cell counts between each indicated condition and the Ascl1 only control. The plots from Collections 1 and 2 used only the control wells collected on their respective days. The dose of each compound is indicated by the size of the dot. ( G ) Quantification of the total cell counts for each treatment. The compound’s dose is indicated by the size of the dot. ( H ) Plots displaying the fold change of Neuron (red) and ProL (orange) cell counts compared to Ascl1 only across all doses for the top hits from the screen. All conditions in which at least 20 cells were recovered are displayed. Figure 2B is created with BioRender.com . Figure 2—source data 1. Small molecules used from Tocriscreen Stem Cell Library. Figure 2—source data 2. Genes used and GO annotations in unknown clusters.
    Figure Legend Snippet: ( A ) Bar plot representing the distribution of targets for the 92 compounds included in the screen. ( B ) Schematic of the experimental design for the small molecule screen. ( C ) UMAP of the MG and MG-derived cell types. Cells are colored by cell type. ( D ) UMAP from C with cells colored by collection. ( E ) Dot plot of the genes used to define the MG-derived cell types from the screen. Dot size indicates the percent of cells that express the gene of interest. The color indicates the log10 mean UMIs per cell. ( F ) Quantification of the fold change in Neuron cell counts between each indicated condition and the Ascl1 only control. The plots from Collections 1 and 2 used only the control wells collected on their respective days. The dose of each compound is indicated by the size of the dot. ( G ) Quantification of the total cell counts for each treatment. The compound’s dose is indicated by the size of the dot. ( H ) Plots displaying the fold change of Neuron (red) and ProL (orange) cell counts compared to Ascl1 only across all doses for the top hits from the screen. All conditions in which at least 20 cells were recovered are displayed. Figure 2B is created with BioRender.com . Figure 2—source data 1. Small molecules used from Tocriscreen Stem Cell Library. Figure 2—source data 2. Genes used and GO annotations in unknown clusters.

    Techniques Used: Derivative Assay, Control



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    Image Search Results


    ( A ) Bar plot representing the distribution of targets for the 92 compounds included in the screen. ( B ) Schematic of the experimental design for the small molecule screen. ( C ) UMAP of the MG and MG-derived cell types. Cells are colored by cell type. ( D ) UMAP from C with cells colored by collection. ( E ) Dot plot of the genes used to define the MG-derived cell types from the screen. Dot size indicates the percent of cells that express the gene of interest. The color indicates the log10 mean UMIs per cell. ( F ) Quantification of the fold change in Neuron cell counts between each indicated condition and the Ascl1 only control. The plots from Collections 1 and 2 used only the control wells collected on their respective days. The dose of each compound is indicated by the size of the dot. ( G ) Quantification of the total cell counts for each treatment. The compound’s dose is indicated by the size of the dot. ( H ) Plots displaying the fold change of Neuron (red) and ProL (orange) cell counts compared to Ascl1 only across all doses for the top hits from the screen. All conditions in which at least 20 cells were recovered are displayed. Figure 2B is created with BioRender.com . Figure 2—source data 1. Small molecules used from Tocriscreen Stem Cell Library. Figure 2—source data 2. Genes used and GO annotations in unknown clusters.

    Journal: eLife

    Article Title: A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    doi: 10.7554/eLife.92091

    Figure Lengend Snippet: ( A ) Bar plot representing the distribution of targets for the 92 compounds included in the screen. ( B ) Schematic of the experimental design for the small molecule screen. ( C ) UMAP of the MG and MG-derived cell types. Cells are colored by cell type. ( D ) UMAP from C with cells colored by collection. ( E ) Dot plot of the genes used to define the MG-derived cell types from the screen. Dot size indicates the percent of cells that express the gene of interest. The color indicates the log10 mean UMIs per cell. ( F ) Quantification of the fold change in Neuron cell counts between each indicated condition and the Ascl1 only control. The plots from Collections 1 and 2 used only the control wells collected on their respective days. The dose of each compound is indicated by the size of the dot. ( G ) Quantification of the total cell counts for each treatment. The compound’s dose is indicated by the size of the dot. ( H ) Plots displaying the fold change of Neuron (red) and ProL (orange) cell counts compared to Ascl1 only across all doses for the top hits from the screen. All conditions in which at least 20 cells were recovered are displayed. Figure 2B is created with BioRender.com . Figure 2—source data 1. Small molecules used from Tocriscreen Stem Cell Library. Figure 2—source data 2. Genes used and GO annotations in unknown clusters.

    Article Snippet: Drugs used were all from the Tocriscreen Stem Cell Library (Tocris, 7340) and were administered in 1 μl of dimethyl sulfoxide (DMSO) at 10 mM.

    Techniques: Derivative Assay, Control